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Christoph von Braun's avatar

Brian, a brilliant paper! Congratulations.

One added thought regarding use of lead by the Romans. This not only occurred in plumbing, but also in the use of lead cups for drinking. Lead was used to give weight, leaf gold to make the cups also look like gold. Over time and with the chemical effects of wine, the gilding gradually wore off and the average consumer drank wine laced with lead. There is a theory that this was a significant contribution to the decline of the Roman Empire.

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Ed P's avatar

Stunning that action didn’t happen earlier. Tetraethyl lead, just from its name, a chemist should immediately be able to tell this is a highly toxic compound. If one was tasked with finding a chemical to efficiently deliver lead to biological systems, tetraethyl lead might be a prime candidate, might even be the first one to try.

But proving causation like you mention is really difficult, especially for humans. We have a whole lot of ethical considerations - can’t just assign people to groups and feed some of them a bunch of poison to study the effect. One cannot control isolate an individual’s environment scientifically for any significant length of time either. So, you don’t have complete data to prove a case.

And if you have an interested party on the other end that is printing money by marketing the dangerous product, they can be very effective running interference, stymie public awareness enough to prevent regulation. We saw this with tobacco a generation ago and climate change for the past several decades. It now seems there is PR misinformation playbook that is very effective at enabling continuation of harmful business practices.

Thanks again for another eye opening article!

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